The 2010 NCAA Division I men's soccer tournament was a tournament of 48 collegiate soccer teams who played for the NCAA Championship in soccer. The semifinals and final were held at Harder Stadium in Santa Barbara, California. All the other games were played at the home field of the higher seeded team (indicated by * for non-seeded teams). The final was held on December 12, 2010. Akron defeated Louisville, 1–0, for the title.
The bracket was announced November 15, 2010. The tournament started on November 18. The second round was played on November 21. The third round was played on November 28. The Regional Finals were played December 3 and 4.
Qualified teams
Automatic bids
All automatic bids are granted for winning a conference championship tournament, except for the automatic bid of the Ivy League, Pacific-10 Conference, and West Coast Conference, each given to the regular season champion. There were 22 automatic bids to the NCAA tournament.