The 2020–21 1. FSV Mainz 05 season was the club's 116th season in existence and the club's 12th consecutive season in the top flight of German football. In addition to the domestic league, 1. FSV Mainz 05 participated in this season's edition of the DFB-Pokal. The season covered the period from 1 July 2020 to 30 June 2021.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: The match was originally scheduled for 18 April 2021, but was postponed after more than ten Hertha players and staff tested positive for COVID-19.[4]
^Due to the impact of the COVID-19 pandemic in Germany and the organisational effort required to host the fixture, the teams exchanged the home rights to the match.[5]