They began their Nigeria Professional Football League campaign with a home tie against city rivals Dakkada, which ended goalless.[3] On 1 August 2021, they beat MFM 5-2 at Godswill Akpabio Stadium to seal the league title. It was their first-ever top-flight triumph.[4] They suffered an early exit from the Aiteo Cup, losing 1-0 to Gateway United in the First Round.[5]
Akwa United were Akwa Ibom State's sole representative in the Aiteo Cup.[7] The Uyo club suffered an early exit from the competition, as they lost to Gateway United 1-0 at the FIFA Goal Project Pitch. Ilechukwu Julius scored the only goal of the game.[8]