The 2021–22 CSA Provincial T20 Knock-Out was a Twenty20 cricket tournament that was played in South Africa in September and October 2021.^[1] It was the first Twenty20 tournament to be played in the country since Cricket South Africa restructured its domestic setup,^[2] and featured all fifteen provincial sides and the national under-19 team.^[3]

From Pool A, South Western Districts and Western Province both advanced to the play-offs.^[4][5] In Group B, Knights and Titans finished first and second respectively to qualify.^[6][7] Group D saw Boland and Warriors reach the play-offs.^[8][9] The final group matches were played in Group C, with Dolphins and North West completing the line-up for the play-off stage.^[10][11]

On the first day of the quarter-finals, Titans beat South Western Districts by 54 runs,^[12] and Knights beat Western Province by four runs.^[13] In the first semi-final, Dolphins beat Titans by four wickets.^[14] The second semi-final finished as no result due to rain, with Knights advancing to the final due to have a better run rate throughout the tournament.^[15] In the final, Knights beat Dolphins by seven runs to win their first domestic title in ten years.^[16]

The teams were placed into the following groups:^[17][18]

• Pool A: Lions, Northern Cape, South Western Districts, Western Province
• Pool B: Knights, KwaZulu-Natal Inland, Mpumalanga, Titans
• Pool C: Dolphins, Easterns, North West, South Africa Under-19s
• Pool D: Boland, Border, Limpopo, Warriors

• Series home at ESPN Cricinfo