Protein-coding gene in humans
Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene .[ 5] [ 6] [ 7]
Clinical significance
It is associated with 3-M syndrome .
Interactions
CUL7 has been shown to interact with RBX1 .[ 5]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000044090 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038545 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex" . Proc Natl Acad Sci U S A . 99 (26): 16601– 6. doi :10.1073/pnas.252646399 PMC 139190 PMID 12481031 . ^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis" . Proc Natl Acad Sci U S A . 100 (17): 9855– 60. Bibcode :2003PNAS..100.9855A . doi :10.1073/pnas.1733908100 PMC 187864 PMID 12904573 . ^ "Entrez Gene: CUL7 cullin 7" .
Further reading
Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene" . Cancer Res . 67 (20): 9616– 22. doi :10.1158/0008-5472.CAN-07-0644 PMID 17942889 . Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function" . Proc. Natl. Acad. Sci. U.S.A . 104 (27): 11388– 93. Bibcode :2007PNAS..10411388J . doi :10.1073/pnas.0609467104 PMC 2040908 PMID 17586686 . Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes" . Cancer Res . 67 (5): 2006– 14. doi :10.1158/0008-5472.CAN-06-3241 PMID 17332328 . Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53" . J. Biol. Chem . 282 (15): 11300– 7. doi :10.1074/jbc.M611297200 PMID 17298945 . Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun . 348 (1): 132– 8. doi :10.1016/j.bbrc.2006.07.013 . PMID 16875676 . Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene . 25 (33): 4534– 48. doi :10.1038/sj.onc.1209490 . PMID 16547496 . S2CID 36894787 . Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet . 37 (10): 1119– 24. doi :10.1038/ng1628 . PMID 16142236 . S2CID 44003147 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805– 11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs" . Genome Res . 12 (11): 1773– 84. doi :10.1101/gr.406902 . PMC 187542 PMID 12421765 . Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins" . Curr. Biol . 9 (20): 1180– 2. Bibcode :1999CBio....9.1180W . doi :10.1016/S0960-9822(00)80021-4 PMID 10531037 . S2CID 14341845 . Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 1 (5): 223– 9. doi :10.1093/dnares/1.5.223 PMID 7584044 .
External links
