Daniel L. Kastner

Daniel L. Kastner
Daniel L. Kastner
Born	8 July 1951 ; Lockport
Alma mater	Princeton University; Baylor College of Medicine ;
Awards	George M. Kober Medal (2024) ;
Website	https://www.genome.gov/staff/Dan-Kastner-MD-PhD

Daniel L. Kastner (born 1951)^[1] is an American physician and researcher specialising in the genetics of autoinflammatory disorders. He is a Distinguished Investigator at the National Institutes of Health and was the Scientific Director of the National Human Genome Research Institute between 2010 to 2021.^[2]^[3] He was awarded the 2021 Crafoord Prize for Polyarthritis for his pioneering work on autoinflammatory diseases.^[4]

Early life and education

Kastner was born in Lockport, NY, in 1951.^[4]

Kastner earned a BA in philosophy from Princeton University in 1973.^[2] and an MD and PhD from Baylor College of Medicine.^[2]

Career

Kastner joined the National Institutes of Health in 1985 and as of 2020^[update] is scientific director of the Division of Intramural Research of the National Human Genome Research Institute. His research there "has focused on using genetic and genomic strategies to understand inherited disorders of inflammation".^[2]

His work has led to the recognition and treatment of a range of autoinflammatory disorders. In 1987 his was one of two teams which simultaneously discovered and published the genetic mutation which causes FMF, and since then he has worked on disorders including TRAPS and DADA2.^[1] In 2020 he was one of the authors of the paper which first described the VEXAS syndrome.^[5]^[6] As of 2021^[update] he is working on Behçet's disease.^[4]

As of 2021^[update] Kastner has said that he plans to leave his post of scientific director at NHGRI "in the next few months". He will continue to work with the 3,000 patients in his clinic, and "find yet more disease genes, understand how they work, and develop new treatments."^[1]

The chair of the Crafoord Prize committee, Olle Kämpe [sv], said in 2021:

Dan Kastner is often called the father of autoinflammatory diseases, a title that he thoroughly deserves. His discoveries have taught us a great deal about the immune system and its functions, contributing to effective treatments that reduce the symptoms of diseases from which patients previously suffered enormously, sometimes leading to premature death^[4]

Honors and recognition

Kastner was elected to the National Academy of Sciences in 2010^[7] and to the National Academy of Medicine in 2012.^[8]

In 2018 Kastner was named "Federal Employee of the Year" in the Samuel J. Heyman Service to America Medals ("the Sammies").^[9]^[10] and in 2019 he won the Ross Prize for Molecular Medicine.^[11]

He was awarded the 2021 Crafoord Prize in Polyarthritis, with the citation "for establishing the concept of autoinflammatory diseases".^[4]^[1]

References

^ ^a ^b ^c ^d Hunt, Katie (2 February 2021). "Mysterious untreatable fevers once devastated whole families. This doctor discovered what caused them". CNN. Retrieved 4 February 2021.
^ ^a ^b ^c ^d "Dan Kastner, M.D., Ph.D." Genome.gov. National Human Genome Research Institute. Archived from the original on 9 January 2021. Retrieved 27 December 2020.
^ "Dan Kastner, M.D., Ph.D." NIH Intramural Research Program: Principal Investigators. Archived from the original on 14 December 2020. Retrieved 27 December 2020.
^ ^a ^b ^c ^d ^e "The Crafoord Prize in Polyarthritis 2021". Crafoord Prize. 31 January 2021. Archived from the original on 1 February 2021. Retrieved 1 February 2021.
^ "VEXAS: how a deadly disease was discovered". www.thenakedscientists.com. 13 November 2020. Archived from the original on 16 March 2021. Retrieved 27 December 2020.
^ Beck, David B.; Ferrada, Marcela A.; Sikora, Keith A.; Ombrello, Amanda K.; Collins, Jason C.; Pei, Wuhong; et al. (27 October 2020). "Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease". New England Journal of Medicine. 383 (27): 2628–2638. doi:10.1056/NEJMoa2026834. PMC 7847551. PMID 33108101.
^ "Daniel L. Kastner". www.nasonline.org. National Academy of Sciences. Archived from the original on 24 March 2019. Retrieved 27 December 2020.
^ "Daniel L. Kastner, M.D., Ph.D." National Academy of Medicine. Retrieved 27 December 2020.
^ Palmer, Kiara S. (October 2, 2018). "NHGRI Scientific Director Dan Kastner Named 2018 Federal Employee of the Year". Genome.gov. Archived from the original on 9 January 2021. Retrieved 27 December 2020.
^ "Daniel L. Kastner, M.D., Ph.D." Samuel J. Heyman Service to America Medals. Archived from the original on 14 January 2021. Retrieved 27 December 2020.
^ "Ross Prize in Molecular Medicine: Past winners". Molecular Medicine. Archived from the original on 12 August 2020. Retrieved 27 December 2020.

External links

Official website
Daniel L. Kastner publications indexed by Google Scholar

[hunt-1] Hunt, Katie (2 February 2021). "Mysterious untreatable fevers once devastated whole families. This doctor discovered what caused them". CNN. Retrieved 4 February 2021.

[nhgri-2] "Dan Kastner, M.D., Ph.D." Genome.gov. National Human Genome Research Institute. Archived from the original on 9 January 2021. Retrieved 27 December 2020.

[3] "Dan Kastner, M.D., Ph.D." NIH Intramural Research Program: Principal Investigators. Archived from the original on 14 December 2020. Retrieved 27 December 2020.

[crafoord-4] "The Crafoord Prize in Polyarthritis 2021". Crafoord Prize. 31 January 2021. Archived from the original on 1 February 2021. Retrieved 1 February 2021.

[naked-5] "VEXAS: how a deadly disease was discovered". www.thenakedscientists.com. 13 November 2020. Archived from the original on 16 March 2021. Retrieved 27 December 2020.

[beck-6] Beck, David B.; Ferrada, Marcela A.; Sikora, Keith A.; Ombrello, Amanda K.; Collins, Jason C.; Pei, Wuhong; et al. (27 October 2020). "Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease". New England Journal of Medicine. 383 (27): 2628–2638. doi:10.1056/NEJMoa2026834. PMC 7847551. PMID 33108101.

[nas-7] "Daniel L. Kastner". www.nasonline.org. National Academy of Sciences. Archived from the original on 24 March 2019. Retrieved 27 December 2020.

[nam-8] "Daniel L. Kastner, M.D., Ph.D." National Academy of Medicine. Retrieved 27 December 2020.

[palmer-9] Palmer, Kiara S. (October 2, 2018). "NHGRI Scientific Director Dan Kastner Named 2018 Federal Employee of the Year". Genome.gov. Archived from the original on 9 January 2021. Retrieved 27 December 2020.

[sammies-10] "Daniel L. Kastner, M.D., Ph.D." Samuel J. Heyman Service to America Medals. Archived from the original on 14 January 2021. Retrieved 27 December 2020.

[ross_prize-11] "Ross Prize in Molecular Medicine: Past winners". Molecular Medicine. Archived from the original on 12 August 2020. Retrieved 27 December 2020.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]