The beginning was in the 2010 CAF Champions League where Espérance de Tunis reached the first final in ten years, The beginning of the journey was against East End Lions and ended with a score of 5–4, in the next round against ASFA Yennenga It ended in victory back and forth with 7–2 on Aggregate, in the last match before the group stage against the Sudanese club Al-Merrikh SC ended with a 4–1 victory on Aggregate, in the group stage draw, Espérance de Tunis fell in Group A with TP Mazembe, ES Sétif and Dynamos where did finish in first place with 13 points. Espérance faced Al Ahly SC from Egypt in the semi-final and lost the first leg 2–1 away from home. In need of a win in the second leg, Espérance were victorious 1–0 and reached the final on the away goals rule.[1] In the final against TP Mazembe, Esperance received a heavy defeat in the first leg 5–0 at Stade Frederic Kibassa Maliba and in the second leg ended 1–1.[2] In the same version, Nigerian striker Michael Eneramo won top goalscorers with 8 goals.
In the next version the goal was to achieve the title, in the first round against ASPAC FC from Benin where they won 5–2 on Aggregate, in the second round against ASC Diaraf won back and forth with 6–0 on Aggregate to qualify for the group stage. were drawn in Group B with Wydad Casablanca, MC Alger and Al Ahly SC finished in first place with 10 points to qualify for the semi-final, where they faced Al-Hilal Club ended with a 3–0 victory on Aggregate.[3] to face in the final Wydad Casablanca Where finished the first leg 0–0 draw and in the second leg at Stade 7 November, Harrison Afful scored the winning goal and won the second title in its history after 17 years.[4] To guarantee a seat in the FIFA Club World Cup for the first time where Espérance finished sixth after losing against Monterrey 3–2.[5] On 25 February 2012, Espérance de Tunis faced Maghreb de Fès the CAF Confederation Cup champion in the CAF Super Cup final and ended in a 4–3 loss on penalties.[6]
^With the score 1–0 in favor of Espérance de Tunis in the 59th minute, Walid El Karti scored a goal for Wydad Casablanca which was subsequently ruled offside by the linesman. Due to a failure of the video assistant referee system, a review of the decision could not be conducted. Believing the goal was valid, Wydad Casablanca protested the decision and the match was interrupted. After 80 minutes of stoppage, the referee ruled the match as a forfeit by Wydad Casablanca and awarded to Espérance de Tunis, securing them the CAF Champions League title.[29] However, on 5 June 2019 the CAF Executive Committee ordered a replay of the second leg at a neutral venue, requiring Espérance de Tunis to return the trophy and medals.[30] However, the decision to order a replay of the second leg was thrown out by the Court of Arbitration for Sport (CAS) on 31 July 2019, who required CAF to refer the case to its proper disciplinary structures for a decision.[31] On 7 August 2019, Espérance de Tunis were again officially declared champions after the CAF Disciplinary Board ruled that Wydad Casablanca "is considered to have lost the game in the 2nd leg."[32]