Interleukin 10 receptor, beta subunit

IL10RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LQM
Identifiers
Aliases	IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta
External IDs	OMIM: 123889; MGI: 109380; HomoloGene: 523; GeneCards: IL10RB; OMA:IL10RB - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,310,187 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,222,722 bp
RNA expression pattern
	Top expressed in
	placenta; ; monocyte; ; blood; ; granulocyte; ; mucosa of transverse colon; ; rectum; ; spleen; ; duodenum; ; appendix; ; gallbladder;
	Top expressed in
	Ileal epithelium; ; adrenal gland; ; cardiac muscle tissue of left ventricle; ; stroma of bone marrow; ; interventricular septum; ; right ventricle; ; granulocyte; ; right lung lobe; ; choroid plexus of fourth ventricle; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; interleukin-10 receptor activity; signaling receptor activity; cytokine receptor activity;
Cellular component	integral component of membrane; interleukin-28 receptor complex; membrane; plasma membrane;
Biological process	inflammatory response; defense response to virus; immune response; signal transduction; cytokine-mediated signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	3588
	16155
	ENSG00000243646
	ENSMUSG00000022969
	Q08334
	Q61190
	NM_000628
	NM_008349
	NP_000619
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.^[5]

IL10RB has also been designated CDw210b (cluster of differentiation w210b).

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243646 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022969 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL10RB interleukin 10 receptor, beta".

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Lutfalla G, Gardiner K, Uzé G (1993). "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR". Genomics. 16 (2): 366–73. doi:10.1006/geno.1993.1199. PMID 8314576.
Gibbs VC, Pennica D (1997). "CRF2-4: isolation of cDNA clones encoding the human and mouse proteins". Gene. 186 (1): 97–101. doi:10.1016/S0378-1119(96)00690-7. PMID 9047351.
Kotenko SV, Krause CD, Izotova LS, et al. (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220. PMID 9312047.
Spencer SD, Di Marco F, Hooley J, et al. (1998). "The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor". J. Exp. Med. 187 (4): 571–8. doi:10.1084/jem.187.4.571. PMC 2212143. PMID 9463407.
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Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Xie MH, Aggarwal S, Ho WH, et al. (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–9. doi:10.1074/jbc.M005304200. PMID 10875937.
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Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. Bibcode:2001PNAS...98.7570L. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
Hollborn M, Kohen L, Wiedemann P, Enzmann V (2001). "The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors". Graefes Arch. Clin. Exp. Ophthalmol. 239 (4): 294–301. doi:10.1007/s004170100263. PMID 11450494. S2CID 676836.
Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi:10.1016/S1074-7613(01)00169-8. PMID 11485736.
Sheppard P, Kindsvogel W, Xu W, et al. (2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119. S2CID 35764259.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kotenko SV, Gallagher G, Baurin VV, et al. (2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nat. Immunol. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210. S2CID 2734534.
Hör S, Pirzer H, Dumoutier L, et al. (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J. Biol. Chem. 279 (32): 33343–51. doi:10.1074/jbc.M405000200. PMID 15178681.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243646 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022969 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL10RB interleukin 10 receptor, beta".

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Interleukin 10 receptor, beta subunit

References

Further reading