Following is a list of notable Wittenberg University alumni.

• George Izenour (BA, 1934; MA 1936), theatre designer, author, and educator
• Jennifer Vanderpool, visual artist
• Helen Bosart Morgan Wagstaff, artist, first president of the Springfield Art Association

• Ronald Fook Shiu Li, founder of the Hong Kong Stock Exchange^[1]
• William C. Martin, founder, Bank of Ann Arbor; founder, First Martin Corp.; former president of the United States Olympic Committee, University of Michigan athletic director
• Matthew Shay, president and CEO of the National Retail Federation
• Adam Willis Wagnalls, Funk & Wagnalls Company co-founder

• Lloyd C. Douglas, minister and author
• Robert J. Marshall, president of the Lutheran Church of America^[2]
• ZeBarney Thorne Phillips, Chaplain of the U.S. Senate, 1927–1942

• Mark A. Boyer, Ph.D. 1988, Professor of Political Science, University of Connecticut^[3]
• Barry Burden, Ph.D. 1998, professor of political science, University of Wisconsin-Madison
• Jonathan Howes (bachelor's degree 1959), Director of the Center for Urban and Regional Studies at the University of North Carolina at Chapel Hill and mayor of Chapel Hill, North Carolina^[4]
• George Philip Krapp, professor of English at Columbia University
• John Warwick Montgomery, Distinguished Research Professor of Philosophy at Concordia University, lawyer, theologian (M.Div., 1958)^[5]
• Robert Bruce Raup, philosopher, writer, professor in the Philosophy of Education, Teachers College, Columbia University
• Karl Weick, organizational theorist at the University of Michigan
• Amanda Knerr,Ph.D. (bachelor's degree), student affairs expert and co-author of The Curricular Approach to Student Affairs: A revolutionary shift for learning beyond the classroom

• John Chowning, American musician, inventor, and professor
• Lauren Schmidt Hissrich, television writer
• Thomas Hyland, professional blackjack player, Blackjack Hall of Fame inductee
• Pierre Lhomme, French cinematographer^[6]
• James Rebhorn, actor
• Barbara Shearer, pianist
• Brendan Wentworth, Actor.

• Fritz W. Ermarth, Director of National Security Programs at the Nixon Center
• Robert C. Henry, first African-American mayor in Ohio
• Douglas E. Lumpkin, director of the Ohio Department of Job and Family Services
• John E. McLaughlin, Deputy Director of the Central Intelligence Agency, senior fellow at the Paul H. Nitze School of Advanced International Studies and Brookings Institution

• Gregory L. Frost, United States federal judge
• Peter S. Grosscup, Judge U.S. Seventh Circuit Court of Appeals, 1899–1911
• James G. Johnson, justice of the Supreme Court of Ohio
• Mary Miller Johnston, judge, Superior Court of Delaware, 2003-2024
• A. John Pelander, justice of the Arizona Supreme Court
• Augustus N. Summers, Justice of the Ohio Supreme Court, 1904–1911
• Shelice Tolbert, attorney in Indiana
• Charles B. Zimmerman, Associate Justice of the Ohio Supreme Court, 1933 and 1934–1949

• James M. Bell, (1837–1919), U.S. Army brigadier general^[7][8]
• Benjamin Thurman Hacker (1935–2003), U.S. Navy Officer, first Naval Flight Officer to achieve flag rank
• Edward Vollrath (attended 1879–1881), U.S. Army brigadier general^[9]

• Sandra Postel, founder and director of the Global Water Policy Project, environmentalist and author.^[10]
• Jere Ratcliffe, Chief Scout Executive of Boy Scouts of America, from 1993 to 2000.

• Jennette Bradley, former Lieutenant Governor of Ohio and Ohio State Treasurer
• Albert Bryan, Governor of the United States Virgin Islands
• Jonathan Howes (bachelor's degree 1959), mayor of Chapel Hill, North Carolina and Director of the Center for Urban and Regional Studies at the University of North Carolina at Chapel Hill^[4]
• Thomas D. Shepard, Los Angeles City Council member, 1961–67
• Sheila Simon, Lieutenant Governor of Illinois
• Walter L. Weaver, U.S. Representative from Ohio

• Brian Agler, basketball coach, formerly the head coach of WNBA's Seattle Storm and Los Angeles Sparks. He now serves as Wittenberg's Athletic Director
• Al Davis, owner of the Oakland Raiders NFL franchise, attended Wittenberg University but graduated from Syracuse University 1950
• Sandy Dukat, athlete
• Mark Henninger, football coach
• Taver Johnson, football coach
• Ron Lancaster, 4-time Grey Cup-winning CFL quarterback and coach, member of the Canadian Football Hall of Fame
• William C. Martin, University of Michigan athletic director, 2000–2009; founder, Bank of Ann Arbor; founder, First Martin Corp.; former president of the United States Olympic Committee
• Eldon Miller – former men's college basketball coach at Wittenberg University, Western Michigan University, Ohio State University, and the University of Northern Iowa

• Paul Dressel (B.A. 1931), American educational psychologist^[11]
• David W. Hertzog, scientist
• Elwood V. Jensen, scientist
• David Ward King, inventor of the King Road Drag
• James Marcia, psychologist of identity development
• Waldo Nelson, pediatrician and author of the Nelson Textbook of Pediatrics
• Hugh M. Raup, botanist and ecologist

• Sherwood Anderson, writer
• Isaac Kaufmann Funk, editor, lexicographer, publisher; founder of Funk & Wagnalls Company publishing firm
• Minnie Willis Baines Miller (A.M.), author
• Brandy Schillace, writer^[12]

• Official website