This is a detailed list of human spaceflights from 1961 to 1970, spanning the Soviet Vostok and Voskhod programs, the start of the Soviet Soyuz program, the American Mercury and Gemini programs, and the first lunar landings of the American Apollo program.

• Red indicates fatalities.
• Green indicates sub-orbital spaceflight (including flights that failed to attain intended orbit).
• Grey indicates flights to the Moon.
• The United States defines spaceflight as any flight reaching an altitude of 50 miles, while the FAI definition requires an altitude of 100 kilometers. During the 1960s, 13 crewed flights of the U.S. North American X-15 rocket plane met the U.S. criteria, of which only two met the FAI's. This article's primary list includes only the latter two flights. A separate, secondary list gives the other eleven which flew between 50 miles and 100 kilometers.

#	Crew	Launch spacecraft	Habitation		Return spacecraft	Brief mission summary
1	Yuri Gagarin	12 April 1961 Vostok 1				First crewed spaceflight. Reached Low Earth Orbit (LEO), flew around the Earth one time.
2	Alan Shepard (1)	5 May 1961 Mercury-Redstone 3 (Freedom 7)				First American crewed spaceflight. Did not reach Earth orbit, maximum altitude: 187 km (116 miles).[1][2]
3	Gus Grissom (1)	21 July 1961 Mercury-Redstone 4 (Liberty Bell 7)				Second American crewed spaceflight. Did not reach Earth orbit, maximum altitude: 190 km (118.26 mi).
4	Gherman Titov	6 August 1961 Vostok 2		7 August 1961 Vostok 2		Day-long flight in LEO. Flew around the Earth 17 times. Brief manual control by pilot.
5	John Glenn (1)	20 February 1962 Mercury-Atlas 6 (Friendship 7)				First American crewed orbital flight. Flew around the Earth three times. It was also the first "completed" orbital human spaceflight per past FAI definitions, because unlike Soviet Vostok missions of that period, the crew landed while remaining inside the spacecraft.[3][4][5][6]
6	Scott Carpenter	24 May 1962 Mercury-Atlas 7 (Aurora 7)				First manual retrofire. Earth photography and study of liquids in weightless conditions.
7	Andriyan Nikolayev (1)	11 August 1962 Vostok 3		15 August 1962 Vostok 3		First instance of two crewed spacecraft in orbit simultaneously.
8	Pavel Popovich (1)	12 August 1962 Vostok 4		15 August 1962 Vostok 4		First instance of two crewed spacecraft in orbit simultaneously.
9	Wally Schirra (1)	3 October 1962 Mercury-Atlas 8 (Sigma 7)				First flawless Mercury mission.
10	Gordon Cooper (1)	15 May 1963 Mercury-Atlas 9 (Faith 7)		16 May 1963 Mercury-Atlas 9 (Faith 7)		First live TV from U.S. astronaut.
11	Valery Bykovsky (1)	14 June 1963 Vostok 5		19 June 1963 Vostok 5		Longest solo spaceflight.
12	Valentina Tereshkova	16 June 1963 Vostok 6		19 June 1963 Vostok 6		First woman in space.
13	Joseph A. Walker	19 July 1963 Flight 90, X-15				First winged craft in space. Reached altitude of 106 km.
14	Joseph A. Walker	22 August 1963 Flight 91, X-15				Reached altitude of 108 km. Walker becomes first person to fly into space twice. X-15-3 (serial 56-6672) becomes first vehicle to fly into space twice.
15	Vladimir Komarov (1) Konstantin Feoktistov Boris Yegorov	12 October 1964 Voskhod 1		13 October 1964 Voskhod 1		First multiple person spaceflight. Biomedical research.
16	Alexei Leonov (1) Pavel Belyayev	18 March 1965 Voskhod 2		19 March 1965 Voskhod 2		First EVA.
17	Gus Grissom (2) John Young (1)	23 March 1965 Gemini 3				First to perform orbital maneuvers.
18	James McDivitt (1) Ed White	3 June 1965 Gemini 4		7 June 1965 Gemini 4		First American EVA.
19	Gordon Cooper (2) Pete Conrad (1)	21 August 1965 Gemini 5		29 August 1965 Gemini 5		First one week spaceflight. Cooper becomes the first person to orbit the Earth on two different missions.
20	Frank Borman (1) Jim Lovell (1)	4 December 1965 Gemini 7		18 December 1965 Gemini 7		First two-week spaceflight. First space rendezvous in history with Gemini 6A.
21	Wally Schirra (2) Thomas P. Stafford (1)	15 December 1965 Gemini 6A		16 December 1965 Gemini 6A		First space rendezvous, with Gemini 7.
22	Neil Armstrong (1) David Scott (1)	16 March 1966 Gemini 8		17 March 1966 Gemini 8		First docking in space in history with Agena Target Vehicle Planned EVA canceled due to early re-entry necessitated by stuck thruster.
23	Thomas P. Stafford (2) Eugene Cernan (1)	3 June 1966 Gemini 9A		6 June 1966 Gemini 9A		First backup crew to fly space mission.
24	John Young (2) Michael Collins (1)	18 July 1966 Gemini 10		21 July 1966 Gemini 10		First rendezvous with two different objects.
25	Pete Conrad (2) Richard F. Gordon Jr. (1)	12 September 1966 Gemini 11		15 September 1966 Gemini 11		Held altitude record prior to lunar missions (1374 km).
26	Jim Lovell (2) Buzz Aldrin (1)	11 November 1966 Gemini 12		15 November 1966 Gemini 12		First manual rendezvous. Miscellaneous scientific experiments.
27	Vladimir Komarov (2)	23 April 1967 Soyuz 1		24 April 1967 Soyuz 1		Crashed on re-entry. First human fatality during a spaceflight.
28	Wally Schirra (3) Donn F. Eisele Walter Cunningham	11 October 1968 Apollo 7		22 October 1968 Apollo 7		First three person U.S. crew. Launched over 20 months after Apollo 1 fatalities.
29	Georgy Beregovoy	26 October 1968 Soyuz 3		30 October 1968 Soyuz 3		Failed to dock with uncrewed Soyuz 2.
30	Frank Borman (2) Jim Lovell (3) William Anders	21 December 1968 Apollo 8		27 December 1968 Apollo 8		First crewed lunar orbit.
31	Vladimir Shatalov (1)	14 January 1969 Soyuz 4		17 January 1969 Soyuz 4		First crew transfer between space vehicles. First docking of two crewed spacecraft.
32	Aleksei Yeliseyev (1) Yevgeny Khrunov	15 January 1969 Soyuz 5		17 January 1969 Soyuz 4		First crew transfer between space vehicles. First docking of two crewed spacecraft.
	Boris Volynov (1)			18 January 1969 Soyuz 5
33	James McDivitt (2) David Scott (2) Rusty Schweickart	3 March 1969 Apollo 9		13 March 1969 Apollo 9		Tested Lunar Module in low Earth orbit.
34	Thomas P. Stafford (3) John Young (3) Eugene Cernan (2)	18 May 1969 Apollo 10		26 May 1969 Apollo 10		Tested Lunar Module in low lunar orbit.
35	Neil Armstrong (2) Michael Collins (2) Buzz Aldrin (2)	16 July 1969 Apollo 11	Moon		24 July 1969 Apollo 11	First lunar landing.
36	Georgy Shonin Valeri Kubasov (1)	11 October 1969 Soyuz 6		16 October 1969 Soyuz 6		First three-craft spaceflight.
37	Anatoly Filipchenko (1) Vladislav Volkov (1) Viktor Gorbatko (1)	12 October 1969 Soyuz 7		17 October 1969 Soyuz 7		First three-craft spaceflight.
38	Vladimir Shatalov (2) Aleksei Yeliseyev (2)	13 October 1969 Soyuz 8		18 October 1969 Soyuz 8		First three-craft spaceflight.
39	Pete Conrad (3) Richard F. Gordon Jr. (2) Alan Bean (1)	14 November 1969 Apollo 12	Moon		24 November 1969 Apollo 12	Second lunar landing. Precision landing near Surveyor 3.
40	Jim Lovell (4) Jack Swigert Fred Haise	11 April 1970 Apollo 13		17 April 1970 Apollo 13		Lunar landing aborted following explosion en route.
41	Andriyan Nikolayev (2) Vitaliy Sevastyanov (1)	1 June 1970 Soyuz 9		19 June 1970 Soyuz 9		Investigations into effects of prolonged spaceflight. Record duration mission for single spacecraft.

In addition to the above spaceflights, eleven flights of the North American X-15 reached a maximum altitude above 50 miles but below 100 kilometers, thus satisfying the U.S. definition of spaceflight but failing to surpass the Kármán line. Among the twelve X-15 pilots, only Neil Armstrong and Joe Engle would travel to space following their participation in the program. Eleven of the thirteen flights above 50 miles were made in the X-15-3, the program's third plane; only two were made in the X-15-1, its first.

In the below table, "spaceflight" and related phrases refer to the American convention.

#	Crew	Launch spacecraft	Habitation		Return spacecraft	Brief mission summary
—	Robert M. White	17 July 1962 X-15 Flight 62				White's only spaceflight. First spaceflight of X-15 program.
—	Joseph A. Walker	17 January 1963 X-15 Flight 77				Walker's first spaceflight.
—	Robert A. Rushworth	27 June 1963 X-15 Flight 87				Rushworth's only spaceflight.
—	Joe Engle	29 June 1965 X-15 Flight 138				Engle's first spaceflight.
—	Joe Engle	10 August 1965 X-15 Flight 143				Engle's second spaceflight.
—	John B. McKay	18 September 1965 X-15 Flight 150				McKay's only spaceflight.
—	Joe Engle	14 October 1965 X-15 Flight 153				Engle's third and last spaceflight, and final flight with X-15 program. First spaceflight of the X-15-1.
—	William H. Dana	1 November 1966 X-15 Flight 174				Dana's first spaceflight.
—	William J. Knight	17 October 1967 X-15 Flight 190				Knight's only spaceflight. Last successful flight of the X-15-3.
—	Michael J. Adams	15 November 1967 X-15 Flight 191				Adams' only spaceflight. Fatal disaster, killing Adams and destroying the X-15-3.
—	William H. Dana	21 August 1968 X-15 Flight 197				Dana's second and last spaceflight. Third-to-last flight of X-15 program. Second and last spaceflight of the X-15-1.

• List of human spaceflight programs
• List of human spaceflights
• List of human spaceflights, 1971–1980
• List of human spaceflights, 1981–1990
• List of human spaceflights, 1991–2000
• List of human spaceflights, 2001–2010
• List of human spaceflights, 2011–2020
• List of human spaceflights, 2021–present

• Vostok and Voskhod flight history
• Mercury flight history
• X-15 flight history (altitudes given in feet)
• Gemini flight history
• Apollo flight history (student resource)
• Skylab flight history
• Apollo-Soyuz flight history
• Space Shuttle flight history infographic
• Shenzhou flight history timeline
• SpaceShipOne flight history