Protein-coding gene in the species Homo sapiens
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene .[ 5] [ 6] [ 7]
Function
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[ 7]
Details on the activity of the N-terminal domain of Mastermind-like protein 1
may be found under MamL-1 .
Interactions
MAML1 has been shown to interact with EP300 [ 8] [ 9] NOTCH1 .[ 5] [ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000161021 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050567 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet . 26 (4): 484– 9. doi :10.1038/82644 . PMID 11101851 . S2CID 23335042 . ^ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters" . Mol Cell Biol . 21 (13): 4337– 46. doi :10.1128/MCB.21.13.4337-4346.2001 . PMC 87094 PMID 11390662 . ^ a b "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)" .^ Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro" . Mol. Cell. Biol . 22 (22): 7812– 9. doi :10.1128/MCB.22.22.7812-7819.2002 . PMC 134732 PMID 12391150 . ^ Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex" . Genes Dev . 16 (11): 1397– 411. doi :10.1101/gad.991602 . PMC 186317 PMID 12050117 . ^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors" . Mol. Cell. Biol . 22 (21): 7688– 700. doi :10.1128/MCB.22.21.7688-7700.2002 . PMC 135662 PMID 12370315 .
Further reading
Alves-Guerra MC, Ronchini C, Capobianco AJ (2007). "Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival" . Cancer Res . 67 (18): 8690– 8. doi :10.1158/0008-5472.CAN-07-1720 PMID 17875709 . Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V (2007). "The notch regulator MAML1 interacts with p53 and functions as a coactivator" . J. Biol. Chem . 282 (16): 11969– 81. doi :10.1074/jbc.M608974200 PMID 17317671 . Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006). "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes" . Cell . 124 (5): 973– 83. doi :10.1016/j.cell.2005.12.037 PMID 16530044 . S2CID 17809522 . Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover" . Mol. Cell . 16 (4): 509– 20. doi :10.1016/j.molcel.2004.10.014 PMID 15546612 . Nam Y, Weng AP, Aster JC, Blacklow SC (2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex" . J. Biol. Chem . 278 (23): 21232– 9. doi :10.1074/jbc.M301567200 PMID 12644465 . Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro" . Mol. Cell. Biol . 22 (22): 7812– 9. doi :10.1128/MCB.22.22.7812-7819.2002 . PMC 134732 PMID 12391150 . Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling" . J. Biol. Chem . 277 (52): 50612– 20. doi :10.1074/jbc.M209529200 PMID 12386158 . Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex" . Genes Dev . 16 (11): 1397– 411. doi :10.1101/gad.991602 . PMC 186317 PMID 12050117 . Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation" . Mol. Cell. Biol . 21 (21): 7403– 15. doi :10.1128/MCB.21.21.7403-7415.2001 . PMC 99913 PMID 11585921 .
