Sarah Martins da SilvaFRCOG is a British gynaecologist and researcher specialising in male infertility. Martins da Silva is a Clinical Reader in reproductive medicine at the University of Dundee. She also works as an honorary consultant gynaecologist at Ninewells Hospital in Dundee, specialising in fertility problems and assisted conception.[2] She was named one of the BBC's "100 Women of 2019" for her contribution to fertility science.[1]
Early life and education
Martins da Silva was born and raised near Cambridge, England.[3] Her father was an engineer and her mother was engaged in charity work.[3] From a young age, she aspired to become a doctor and scientist.[3]
From 2011 to 2013, Martins da Silva was a Scottish Clinical Research Excellence Development Scheme (SCREDS) Clinical Lecturer in reproductive medicine at the University of Dundee School of Medicine. From 2013 to 2019, Martins da Silva was a consultant gynaecologist and honorary senior lecturer at Ninewells Hospital at NHS Tayside in Dundee, Scotland.
In 2021, Martins da Silva became Clinical Reader in reproductive medicine and an honorary Consultant Gynaecologist at the University of Dundee School of Medicine.
In addition to her research in sperm count and function, Martins da Silva is a consultant gynecologist and fertility specialist, including in the area of freezing eggs.[8]
In 2019, Martins da Silva featured in a BBC documentary on fertility issues and IVF.[9] She delivered a speech highlighting the problem of decreasing sperm counts at the BBC 100 Women event in Delhi, India.[10]
Research
Martins da Silva leads a research group on male infertility, sperm biology and drug discovery.[11] She is the lead on a UK-wide research clinic on sperm studies for couples affected by unexplained infertility post-IVF treatment.[2] Da Silva has published scientific papers predominantly focussing on human fertility.[5]
Martins da Silva's work on male infertility was motivated by the unexplained decrease in male fertility in the late 20th and early 21st centuries.[10] During her work as a consultant gynaecologist specialising in fertility problems and assisted conception, she noticed that treatment options for male fertility were limited, instead requiring the female partner to undergo invasive fertility treatments such as in-vitro fertilisation (IVF) and intracytoplasmic sperm injection that did not directly address the problem of low male fertility.[12] Martins da Silva's research investigates the functionality of sperm cells, particularly the sperm-specific calcium channelCatSper, and how modern lifestyle choices may affect sperm function.[13][14] She is working on developing drugs to enhance sperm count and function, for which she has won funding from the Bill & Melinda Gates Foundation.[15][16] Martins da Silva helped create a high-throughput system for screening many potential drugs, an approach which led to the discovery of two compounds that were able to enhance sperm motility in laboratory tests.[17]
Personal life
Martins da Silva married fellow medic Mauricio Martins da Silva in 2000. They met while studying at the University of Edinburgh.[3] They have three children.
Martins Da Silva, Sarah Justine (2007). Activin and Neurotrophin Regulation of Human Follicular Development and Bovine Oocyte Maturation (PhD). University of Edinburgh. hdl:1842/24911. OCLC1065314574.
^De Sousa, P.a.; Martins Da Silva, S.j.; Anderson, R.a. (1 December 2004). "Neurotrophin Signaling in Oocyte Survival and Developmental Competence: A Paradigm for Cellular Toti-Potency". Cloning and Stem Cells. 6 (4): 375–385. doi:10.1089/clo.2004.6.375. ISSN1536-2302. PMID15671666.
^Martins Da Silva, Sarah Justine (2007). Activin and Neurotrophin Regulation of Human Follicular Development and Bovine Oocyte Maturation (PhD). University of Edinburgh. hdl:1842/24911. OCLC1065314574.
