The Grenada, Mississippi, tornado of May 7, 1846, killed 21 people, injured 60, and destroyed 60 or 70 buildings in the southern half of Grenada, Yalobusha County, Mississippi^[a] in the United States.^[1][2][3] Other accounts had it that 112 buildings were destroyed,^[4] including 17 homes.^[5] Property damage was estimated at $65,000^[6] to US$80,000 (equivalent to $2,712,889 in 2023).^[4] According to the Mississippi Democrat of Carrollton, Mississippi, "When the tornado passed through Grenada it must have been at least 600 yards (550 m) from one extreme to the other; but about the centre and 50 yards (46 m) each way therefrom, the principal damage was done."^[7]

According to the New Orleans Picayune, "On the outside of a letter to a friend, is written the words, 'Grenada is in ruins, and many of her inhabitants are destroyed; names cannot be given, or numbers set down."^[8] The tornado struck at about 2:30 p.m.^[5] Both schools in the town were in session at the time the hurricane struck, and both were destroyed.^[9] The teacher of the girls' school was killed, her body was found across the river in a tree.^[9] The force of the tornado "shattered" the logs of the cabin that housed the girls' school.^[9] The teacher of the boys' school survived but was seriously injured.^[9] The newly built Baptist church was leveled.^[6][10]

According to a scrapbooked clipping of a news article entitled "The Great Hurricane," written by Aaron Davis, the tornado approached the town from the west.^[11] The same tornado later continued northward into Maury County, Tennessee, where there were no casualties but three farms were damaged.^[12]

• 1840 Natchez tornado