In enzymology, an acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction

1-palmitoylglycerol 3-phosphate + NADP⁺ ${\displaystyle \rightleftharpoons }$ palmitoylglycerone phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are 1-palmitoylglycerol 3-phosphate and NADP⁺, whereas its 3 products are palmitoylglycerone phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP⁺ oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.

• LaBelle EF, Hajra AK (September 1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". The Journal of Biological Chemistry. 247 (18): 5825–34. PMID 4403490.