Anna Lucia de Amicis (c. 1745–1816) was an Italian soprano.^[1]

The daughter of tenor Domenico de Amicis and soprano Rosalba Baldacci, Anna Lucia de Amicis was born in Naples, Italy in c.1745. She had her initial vocal training from her parents and later studied with Vittoria Tesi. She made her professional opera debut in Pisa in the Spring of 1754 at the age of nine in Giacomo Cordella’s Il cicisbeo impertinente. She appeared in comic operas with her parents in Florence (1754) and Bologna (1755), and then the family toured in concerts and operas throughout Europe to Lyon (1756–7), Paris (1758), Brussels (1759), Antwerp (1759), Ghent (1760), The Hague (1760), Amsterdam (1761), Dublin (1761–2), and London (1762–3).^[1]

She appeared in J. C. Bach's Orione in London, and went on to sing as prima donna in Dublin,^[2] Innsbruck and Naples. In Innsbruck she sang the female title role in Romolo ed Ersilia, the marriage celebration opera written by Johann Adolf Hasse for the marriage of Leopold of Habsburg and Spanish Infanta Maria Ludovica. For this role she gained a noted reputation. She was a favourite of both W. A. Mozart and his father, Leopold, and created the role of Giunia in Lucio Silla (Milan 1772).^[3]