Delta Sigma may refer to:

• Delta Sigma fraternity, a secondary school fraternity founded in 1897 at Lewis Institute in Chicago, Illinois
• Delta Sigma (sorority), a collegiate sorority founded in 1895 at Tufts University and later absorbed by Alpha Omicron Pi
• Delta-sigma modulation, a pulse density modulation scheme used in analog-to-digital and digital-to-analog conversions

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