Research and Innovation Center in Israel
The Kahn-Sagol-Maccabi (KSM) for Research and Innovation (in Hebrew: מכון קאהן-סגול-מכבי למחקר ולחדשנות) is the Research and Innovation Center of Maccabi Healthcare Services .[ 1]
History
Founded in 2016 by Maccabi Health Services with the key support of Morris Kahn and Sami Sagaol, KSM promotes excellence in medical research.[ 2]
It wasa formerly headed by Prof. Varda Shalev and is currently headed by Dr. Tal Patalon .[ 3]
Activities and services
Medical studies
KSM Center strives to enhance healthcare systems through independent research and partnerships with international researchers,[ 4] [ 5] [ 6]
Since its inception, the center has conducted hundreds of studies,[ 7] [ 8] COVID-19 pandemic .[ 9]
Notable studies conducted under KSM's auspices include:
Studies on the coronavirus epidemic – During the COVID-19 pandemic , several international scientific studies based on the Maccabi databases were conducted by the center, Including studies on repeated infection in children,[ 10] [ 11] [ 12] [ 9] [ 13] [ 14] [ 15] [ 16] Research on mpox – In 2023, a study on mpox based on KSM's analysis and database was published.[ 17] Research on Parvovirus B19 – In 2023, a study on a local outbreak of parvovirus was published.[ 18] Research on autism – In 2023, a study on late diagnosis of autism was published.[ 19] Research on cancer – In 2023, a study of the effects of palbociclib treatment on the lifespan of patients with breast cancer was published.[ 20]
Medical database
KSM's research activities are based on independent efforts, as well as the extensive medical knowledge and database of Maccabi Health Services.[ 21] database , compiled over three decades and anonymized, encompasses digital records of 2.7 million insured individuals.[ 22]
In addition to its in-house research,[ 23] [ 24] [ 25]
KSM's innovation and big data department leverages databases and artificial intelligence technologies,[ 26] [ 27] [ 28]
Biobank
The KSM Center has established the Tipa BioBank,[ 29] [ 30] [ 31] [ 8]
The purpose of this initiative is to develop tools for early disease detection through genetic[ 32] [ 33] [ 34]
Main publications
Gazit, Sivan; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Stuart, Elizabeth A.; Patalon, Tal (2023). "Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation" . The Lancet Microbe . 4 (7): e495 – e505 . doi :10.1016/S2666-5247(23)00103-9 . PMC 10101759 PMID 37062294 . Shapira, Guy; Patalon, Tal; Gazit, Sivan; Shomron, Noam (2023). "Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift" . Viruses . 15 (4): 855. doi :10.3390/v15040855 PMC 10145566 PMID 37112835 . Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents" . The Journal of Pediatrics . 257 . doi :10.1016/j.jpeds.2023.02.016 . PMC 9981270 PMID 36870558 . Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study" . Clinical Infectious Diseases . 75 (1): e545 – e551 . doi :10.1093/cid/ciac262 . PMC 9047157 PMID 35380632 . Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine" . Annals of Internal Medicine . 175 (5): 674– 681. doi :10.7326/M21-4130 . PMC 8855786 PMID 35157493 . Ben-Tov, Amir; Lebwohl, Benjamin; Banon, Tamar; Chodick, Gabriel; Kariv, Revital; Assa, Amit; Gazit, Sivan; Patalon, Tal (2023). "BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign" . Viruses . 15 (9): 1968. doi :10.3390/v15091968 PMC 10534420 PMID 37766374 . Lechtman, Niva; Shamir, Raanan; Cohen, Shlomi; Chodick, Gabriel; Kariv, Revital; Supino-Rosin, Lia; Weintraub, Yael; Yerushalmy-Feler, Anat; Ben Tov, Amir (2021). "Increased incidence of coeliac disease autoimmunity rate in Israel: A 9-year analysis of population-based data". Alimentary Pharmacology & Therapeutics . 53 (6): 696– 703. doi :10.1111/apt.16282 . PMID 33547687 . S2CID 231946967 .
References
^ The Kahn-Sagol-Maccabi (KSM) Institute for Research and Innovation ^ "Kahn Sagol Maccabi" . Guidestar . Retrieved 9 November 2023 .^ Big data unit Kahn-Sagol-Maccabi (KSM)^ Neesha Salian, SEHA and Israel’s leading HMO announce collaboration in research and digital health development , Gulf Business, 13 July 2022
^ Maccabi’s KSM Research and Innovation Center Announces Partnership with Rhino Health to Facilitate Healthcare Data Collaborations , Accesswire 25 October 2022^ PrognomiQ, Maccabi Health Collaborating on Cancer Biomarker Development , 360dx.com, 21 June 2022^ Professional publications , KSM Research and Innovation Center^ a b Rubinstein, Carrie (9 September 2022). "Small-Big Data: A Healthcare Revolution In The Making" . Forbes . Retrieved 26 October 2023 . ^ a b Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents" . The Journal of Pediatrics . 257 . doi :10.1016/j.jpeds.2023.02.016 . PMC 9981270 PMID 36870558 . ^ Gazit, Sivan; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Stuart, Elizabeth A.; Patalon, Tal (2023). "Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation" . The Lancet Microbe . 4 (7): e495 – e505 . doi :10.1016/S2666-5247(23)00103-9 . PMC 10101759 PMID 37062294 . ^ Gazit, S.; Shlezinger, R.; Perez, G.; Lotan, R.; Peretz, A.; Ben-Tov, A.; Herzel, E.; Alapi, H.; Cohen, D.; Muhsen, K.; Chodick, G.; Patalon, T. (2022). "The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine: A Retrospective Cohort Study" . Annals of Internal Medicine . 175 (5): 674– 681. doi :10.7326/M21-4130 . PMC 8855786 PMID 35157493 . ^ Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents" . The Journal of Pediatrics . 257 . doi :10.1016/j.jpeds.2023.02.016 . PMC 9981270 PMID 36870558 . ^ van Boven, Michiel; van Dorp, Christiaan H.; Westerhof, Ilse; et al. (29 January 2024). "Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study" . PLOS Computational Biology . 20 (1): e1011832. doi :10.1371/journal.pcbi.1011832 ISSN 1553-7358 . medRxiv 10.1101/2023.06.02.23290879 PMC 10852262 PMID 38285727 . ^ Patalon, Tal; Saciuk, Yaki; Peretz, Asaf; Perez, Galit; Lurie, Yoav; Maor, Yasmin; Gazit, Sivan (2022). "Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine" . Nature Communications . 13 (1): 3203. Bibcode :2022NatCo..13.3203P . doi :10.1038/s41467-022-30884-6 . PMC 9184525 PMID 35680872 . ^ Prunas, Ottavia; Warren, Joshua L.; Crawford, Forrest W.; Gazit, Sivan; Patalon, Tal; Weinberger, Daniel M.; Pitzer, Virginia E. (2022). "Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel" . Science . 375 (6585): 1151– 1154. Bibcode :2022Sci...375.1151P . doi :10.1126/science.abl4292 . PMC 9261115 PMID 35084937 . ^ Ben-Tov, Amir; Lebwohl, Benjamin; Banon, Tamar; Chodick, Gabriel; Kariv, Revital; Assa, Amit; Gazit, Sivan; Patalon, Tal (2023). "BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign" . Viruses . 15 (9): 1968. doi :10.3390/v15091968 PMC 10534420 PMID 37766374 . ^ Patalon, Tal; Perez, Galit; Saciuk, Yaki; Refaeli, Ziva; Gazit, Sivan (2023). "Mpox Patient Journey in Israel" . Microorganisms . 11 (4): 1042. doi :10.3390/microorganisms11041042 PMC 10145053 PMID 37110465 . ^ Patalon, Tal; Saciuk, Yaki; Trotzky, Daniel; Pachys, Gal; Ben-Tov, Amir; Segal, Yaakov; Gazit, Sivan (2023). "An Outbreak of Parvovirus B19 in Israel" . Viruses . 15 (11): 2261. doi :10.3390/v15112261 PMC 10674631 PMID 38005937 . ^ Davidovitch, Michael; Gazit, Sivan; Patalon, Tal; Leitner, Yael; Rotem, Ran S. (2023). "Late diagnosis of autism spectrum disorder—Journey, parents' concerns, and sex influences". Autism Research . 16 (2): 294– 301. doi :10.1002/aur.2869 . PMID 36495248 . S2CID 254561408 . ^ Moser, Sarah Sharman; Mazursky, Orr Friedman; Shalev, Hadas; Apter, Lior; Chodick, Gabriel; Siegelmann-Danieli, Nava (2023). "Real-world outcomes of patients with metastatic endocrine-responsive breast cancer receiving palbociclib-based combinations" . Future Oncology . 19 (21): 1473– 1483. doi :10.2217/fon-2023-0176 PMID 37529919 . ^ Valo Health, KSM research and innovation center and Valo health announce first of its kind multiyear collaboration to spearhead preventive care and personalized medicine for patients , 19 Sep 2022
^ Kraus, Yair (1 August 2023). " . Ynet . Retrieved 9 November 2023 . ^ Yanko, Adir (25 March 2021). "A significant increase in the diagnosis of young celiac patients in Israel – what are the reasons for this?" . Ynet . Retrieved 26 October 2023 . ^ Yechezkel, Matan; Mofaz, Merav; Painsky, Amichai; Patalon, Tal; Gazit, Sivan; Shmueli, Erez; Yamin, Dan (2023). "Safety of the fourth COVID-19 BNT162b2 mRNA (Second booster) vaccine: A prospective and retrospective cohort study" . The Lancet Respiratory Medicine . 11 (2): 139– 150. doi :10.1016/S2213-2600(22)00407-6 . PMC 9889528 PMID 36410364 . ^ Weinerb, Gali (1 December 2020). "Predicting illnesses and hospitalizations: the vision of the director of the Maccabi Research Institute" . Globes . Retrieved 26 October 2023 . ^ Danny Sullivan, Longevity AI partners with Israel’s leading HMO , Technology, 4 April 2023
^ IBEX Introduces Galen Gastric, World’s First AI-Powered Solution For Gastrointestinal Cancer Diagnostics, At Maccabi Healthcare Services , AIthority.com, 24 August 2021^ Suresh, Somasetty (25 October 2023). "New Study Shows Pfizer COVID-19 Vaccine Equally Effective for Patients with Celiac Disease" . Express Healthcare Management. Retrieved 26 October 2023 . ^ The Tipa Biobank , Kahn-Sagol-Maccabi (KSM)^ KSM Research And Innovation And Genetika+ Partner To Seek AI Solutions For Personalization Of Depression Treatment , 15 August 2022^ "Abu Dhabi DoH and Kahn Sagol Maccabi (KSM) Sign an MoU to Cooperate in Technological Innovation and Healthcare Research" . AP news . 1 February 2023. Retrieved 26 October 2023 .^ G42 Healthcare, KSM enter first UAE-Israel genetic research collaboration – Arabian Business , Arabian Business, 2 March 2022^ Rubinstein, Carrie (12 July 2023). "Apparently Getting Smarter Makes Us Healthier: AI And Data Analysis Revolutionize Healthcare" . Forbes . Retrieved 26 October 2023 . ^ Israel and UAE to collaborate on cancer and diabetes research , MiddleEastMonitor ,14 July 2022
External links
Information related to Kahn Sagol Maccabi
