Irani-British neural engineer
Parastoo Hashemi
Parastoo ("Parry") Hashemi (born 1980) is an Iranian-British neural engineer at Imperial College London .
Hashemi's research develops and applies sensors for brain measurements of neurotransmitters in the context of mental illness etiology, diagnosis and treatment.[ 1] [ 2]
Life and academic career
Early life
Hashemi was born in Tehran, Iran and immigrated with her family to the United Kingdom, as a child, in 1986. She grew up in Durham, UK and attended Belmont Comprehensive school and Durham Johnston 6th Form College.
Hashemi graduated with a first class Master in Science (MSci) degree in chemistry from King's College London in 2003.[ 2] She received her PhD in Bioengineering from Imperial College London in 2007 under the mentorship of Dr. Martyn Boutelle.[ 2] [ 3] The focus of her Ph.D. research was to develop online microdialysis techniques for monitoring humans with traumatic brain injury.[ 2]
Hashemi moved to the United States in 2007 to perform her post-doctoral work with Dr. R. Mark Wightman at the University of North Carolina at Chapel Hill .[ 2] [ 3] The focus of her post-doctoral research was to develop a selective method for in vivo detection for brain serotonin .[ 2] [ 4]
Positions held
Hashemi held an assistant professorship in the department of Chemistry at Wayne State University [ 2] from 2011 to 2015 and in the department of Chemistry and Biochemistry at the University of South Carolina[ 2] from 2015-2022 where she was tenured in 2017. Hashemi continues to run her lab as a Reader in Brain Diagnostics and Therapeutics in the Department of Bioengineering at Imperial College London [ 5] since 2019.[ 6]
Research
Hashemi has pioneered tools for measurements of serotonin in the brain,[ 2] [ 7] [ 8] [ 9] a neurotransmitter important in the pathology of depression . Her team is using these tools in a variety of models to better understand, diagnose and treat mental disorders, with a focus on depression.[ 10]
Notable awards
2019 CAMS Fellow (Community for Analytical Measurement Science)
2018 Society for Electroanalytical Chemistry (SEAC) Royce W. Murray Award[ 11]
2018 Society of Pittsburgh Chemists Pittcon Achievement Award[ 12]
2018 USC Breakthrough Stars Award[ 13]
2017 Midwestern Universities Analytical Chemistry Conference Young Investigator Travel Award
2017 International Society for Neurochemistry Brain in Flux Symposium Young Faculty Travel Award
2017 NSF CAREER Award[ 14]
2015 Eli Lilly Young Investigator Award in Analytical Chemistry
2013 Masao Horiba Award for Analytical Chemistry[ 15]
Notable papers
Hersey, Melinda; Samaranayake, Srimal; Berger, Shane N.; Tavakoli, Navid; Mena, Sergio; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Blakely, Randy D.; Reagan, Lawrence P.; Hashemi, Parastoo (2021-07-28). "Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin" . Journal of Neuroscience . 41 (30): 6564– 6577. doi :10.1523/JNEUROSCI.2618-20.2021 . ISSN 0270-6474 . PMC 8318079 . PMID 34083254 .
West, Alyssa; Best, Janet; Abdalla, Aya; Nijhout, H. Frederik; Reed, Michael; Hashemi, Parastoo (2019-02-01). "Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex" . Neurochemistry International . Brain in Flux-III. 123 : 50– 58. doi :10.1016/j.neuint.2018.07.004 . ISSN 0197-0186 . PMC 7448101 . PMID 30031052 .
Abdalla, Aya; West, Alyssa; Jin, Yunju; Saylor, Rachel A.; Qiang, Beidi; Peña, Edsel; Linden, David J.; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Hashemi, Parastoo (2020). "Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology" . Journal of Neurochemistry . 153 (1): 33– 50. doi :10.1111/jnc.14854 . ISSN 1471-4159 . PMC 7279511 . PMID 31419307 .
Jin, Yunju; Dougherty, Sarah E.; Wood, Kevin; Sun, Landy; Cudmore, Robert H.; Abdalla, Aya; Kannan, Geetha; Pletnikov, Mikhail; Hashemi, Parastoo; Linden, David J. (2016-08-17). "Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury" . Neuron . 91 (4): 748– 762. doi :10.1016/j.neuron.2016.07.024 . ISSN 0896-6273 . PMC 4990493 . PMID 27499084 .
Atcherley, Christopher W.; Wood, Kevin M.; Parent, Kate L.; Hashemi, Parastoo; Heien, Michael L. (2015-01-27). "The coaction of tonic and phasic dopamine dynamics" . Chemical Communications . 51 (12): 2235– 2238. doi :10.1039/C4CC06165A . ISSN 1364-548X . PMC 4825181 . PMID 25249291 .
References
^ "Parastoo Hashemi: Tackling Complex Biological and Environmental Problems" . 2 March 2017.
^ a b c d e f g h i "CV of Parastoo Hashemi" (PDF) .
^ a b "Chemistry Tree - Parastoo Hashemi Family Tree" .
^ Hashemi, Parastoo; Dankoski, Elyse C.; Petrovic, Jelena; Keithley, Richard B.; Wightman, R. Mark (2009). "Voltammetric Detection of 5-Hydroxytryptamine Release in the Rat Brain" . Analytical Chemistry . 81 (22): 9462– 9471. doi :10.1021/ac9018846 . PMC 2783829 . PMID 19827792 .
^ "Academic staff and research fellows | Faculty of Engineering | Imperial College London" .
^ "The Bioengineering Immuno-Pathology Network at Imperial College London" . Imperial College London Bioengineering Page for Immuno-Pathology Network . 25 January 2024. Retrieved 25 January 2024 .
^ Wood, Kevin M.; Zeqja, Anisa; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Hashemi, Parastoo (2014). "Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo" . Journal of Neurochemistry . 130 (3): 351– 359. doi :10.1111/jnc.12733 . ISSN 1471-4159 . PMC 4107184 . PMID 24702305 .
^ Abdalla, Aya; Atcherley, Christopher W.; Pathirathna, Pavithra; Samaranayake, Srimal; Qiang, Beidi; Peña, Edsel; Morgan, Stephen L.; Heien, Michael L.; Hashemi, Parastoo (2017-09-07). "In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes" . Analytical Chemistry . 89 (18): 9703– 9711. doi :10.1021/acs.analchem.7b01257 . ISSN 0003-2700 . PMC 5837047 . PMID 28795565 .
^ Saylor, Rachel A.; Hersey, Melinda; West, Alyssa; Buchanan, Anna Marie; Berger, Shane N.; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Hashemi, Parastoo (2019). "In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry" . Frontiers in Neuroscience . 13 : 362. doi :10.3389/fnins.2019.00362 . ISSN 1662-453X . PMC 6499219 . PMID 31110471 .
^ Hersey, Melinda; Samaranayake, Srimal; Berger, Shane N.; Tavakoli, Navid; Mena, Sergio; Nijhout, H. Frederik; Reed, Michael C.; Best, Janet; Blakely, Randy D.; Reagan, Lawrence P.; Hashemi, Parastoo (2021-07-28). "Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin" . Journal of Neuroscience . 41 (30): 6564– 6577. doi :10.1523/JNEUROSCI.2618-20.2021 . ISSN 0270-6474 . PMC 8318079 . PMID 34083254 .
^ "Awards Information - Charles N. Reilley, Y.I., and Travel" .
^ "Pittcon Announces 2018 Award Recipients for Outstanding Achievements in Analytical Chemistry and Applied Spectroscopy" . 2 October 2017.
^ "2018 Breakthrough Awards Cover the Academic Spectrum - Office of the Vice President for Research | University of South Carolina" .
^ "NSF Award Search: Award#1654111 - CAREER: The fundamental principles of modified carbon fiber microelectrodes as speciation sensors" .
^ "2013 | Masao Horiba Awards / 堀場雅夫賞" .
External links
Information related to Parastoo Hashemi