Protein-coding gene in the species Homo sapiens
Protein SSXT is a protein that in humans is encoded by the SS18 gene .[ 5] [ 6] [ 7]
Function
SS18 is a member of the human SWI/SNF chromatin remodeling complex.[ 8] [ 9] [ 10]
Clinical significance
SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma .[ 11]
Interactions
SS18 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141380 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037013 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene . 9 (5): 1447– 53. PMID 8152806 . ^ Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics . 7 (4): 502– 8. doi :10.1038/ng0894-502 . PMID 7951320 . S2CID 20503729 . ^ de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research . 112 (3– 4): 222– 6. doi :10.1159/000089874 . PMID 16484776 . ^ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes" . PLOS ONE . 7 (3): e33834. Bibcode :2012PLoSO...733834M . doi :10.1371/journal.pone.0033834 PMC 3307773 PMID 22442726 . ^ a b Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones" . The Journal of Biological Chemistry . 277 (7): 5498– 505. doi :10.1074/jbc.M108702200 hdl :2066/170683 PMID 11734557 . ^ a b Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers" . Oncogene . 22 (50): 8156– 67. doi :10.1038/sj.onc.1207031 PMID 14603256 . ^ Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas" . Oncogene . 21 (26): 4181– 90. doi :10.1038/sj.onc.1205569 PMID 12037676 . ^ Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion" . Cell . 102 (6): 839– 48. doi :10.1016/S0092-8674(00)00072-6 PMID 11030627 . S2CID 17342132 . ^ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10" . Oncogene . 20 (25): 3281– 9. doi :10.1038/sj.onc.1204419 PMID 11423977 .
Further reading
Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript" . The American Journal of Pathology . 147 (6): 1592– 9. PMC 1869933 PMID 7495284 . Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies" . Human Molecular Genetics . 6 (9): 1559– 64. doi :10.1093/hmg/6.9.1559 PMID 9285794 . Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus" . Human Molecular Genetics . 8 (4): 585– 91. doi :10.1093/hmg/8.4.585 PMID 10072425 . Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion" . Cell . 102 (6): 839– 48. doi :10.1016/S0092-8674(00)00072-6 PMID 11030627 . S2CID 17342132 . Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma" . British Journal of Cancer . 84 (8): 1087– 94. doi :10.1054/bjoc.2000.1710 . PMC 2363857 PMID 11308259 . Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O (May 2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene . 268 (1– 2): 173– 82. doi :10.1016/S0378-1119(01)00412-7 . PMID 11368913 . de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10" . Oncogene . 20 (25): 3281– 9. doi :10.1038/sj.onc.1204419 PMID 11423977 . Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" (PDF) . Genome Research . 11 (10): 1758– 65. doi :10.1101/gr.180101 . PMC 311163 PMID 11591653 . Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones" . The Journal of Biological Chemistry . 277 (7): 5498– 505. doi :10.1074/jbc.M108702200 hdl :2066/170683 PMID 11734557 . Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas" . Oncogene . 21 (26): 4181– 90. doi :10.1038/sj.onc.1205569 PMID 12037676 . Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A (Aug 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research . 288 (1): 35– 50. doi :10.1016/S0014-4827(03)00130-7 . PMID 12878157 . Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers" . Oncogene . 22 (50): 8156– 67. doi :10.1038/sj.onc.1207031 PMID 14603256 . Iwasaki T, Koibuchi N, Chin WW (Sep 2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator" . Endocrinology . 146 (9): 3892– 9. doi :10.1210/en.2004-1513 PMID 15919756 . Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M (Mar 2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma" . International Journal of Cancer . 118 (5): 1165– 72. doi :10.1002/ijc.21475 PMID 16152617 . S2CID 12084422 . Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins" . The Journal of Biological Chemistry . 280 (52): 42863– 76. doi :10.1074/jbc.M502963200 PMID 16227627 . Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S (Feb 2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1" . Oncogene . 25 (7): 1042– 52. doi :10.1038/sj.onc.1209143 PMID 16247461 .
Information related to SS18
