Small nucleolar RNA SNORD67
Predicted secondary structure and sequence conservation of SNORD67
Identifiers
Symbol	SNORD67
Alt. Symbols	snoHBII-166
Rfam	RF00573
Other data
RNA type	Gene; snRNA; snoRNA; C/D-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

In molecular biology, SNORD67 (also known as HBII-166) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBII-166 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1]

snoRNA HBII-166 is the human orthologue of the mouse MBII-166^[2] and is predicted to guide 2'O-ribose methylation of spliceosomal RNA U6 at residue C60.^[3]

• Page for Small nucleolar RNA SNORD67 at Rfam
• Entry for SNORD67 at snoRNABase

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