Terbinafine/betamethasone acetate, sold under the brand name Duotic is a veterinary medication used for the treatment of otitis externa (ear infections) in dogs.^[1] It is a fixed dose combination of terbinafine, an antifungal; and betamethasone acetate, a glucocorticosteroid anti-inflammatory.^[1][2]

The combination is the first FDA-approved animal drug intended to treat yeast-only otitis externa in dogs.^[2] It is also the first otic drug intended to treat otitis externa that does not contain an antibiotic.^[2]

Terbinafine/betamethasone acetate was approved for medical use in the United States in March 2024.^[1][2]

In October 2024, the Committee for Veterinary Medicinal Products of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the veterinary medicinal product Duotic, Ear gel, intended for dogs.^[3] The applicant for this veterinary medicinal product is Dechra Regulatory B.V.^[3]

Terbinafine/betamethasone acetate is indicated for the treatment of otitis externa in dogs, associated with susceptible strains of yeast (Malassezia pachydermatis).^[1][2]

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