UGDH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q3E, 2QG4, 3ITK, 3KHU, 3PRJ, 3PTZ, 3TDK, 3TF5, 4EDF, 4QEJ, 4RJT
Identifiers
Aliases	UGDH, GDH, UDP-GlcDH, UDPGDH, UGD, UDP-glucose 6-dehydrogenase, EIEE84, DEE84
External IDs	OMIM: 603370; MGI: 1306785; HomoloGene: 2520; GeneCards: UGDH; OMA:UGDH - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 39,498,755 bp[1] End 39,528,311 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 33.67 cM Start 65,570,564 bp[2] End 65,593,292 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon islet of Langerhans mucosa of transverse colon vena cava rectum mucosa of ileum decidua bronchial epithelial cell liver Top expressed in olfactory epithelium upper arm colon autopod region hand stomach duodenum epidermis proximal tubule metanephros More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NAD binding catalytic activity oxidoreductase activity electron transfer activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor UDP-glucose 6-dehydrogenase activity Cellular component nucleoplasm extracellular exosome nucleus cytosol Biological process UDP-glucuronate biosynthetic process gastrulation with mouth forming second metabolism UDP-glucose metabolic process glycosaminoglycan biosynthetic process electron transport chain heparan sulfate proteoglycan biosynthetic process chondroitin sulfate biosynthetic process protein hexamerization carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7358 22235 Ensembl ENSG00000109814 ENSMUSG00000029201 UniProt O60701 O70475 RefSeq (mRNA) NM_001184700 NM_001184701 NM_003359 NM_009466 RefSeq (protein) NP_001171629 NP_001171630 NP_003350 NP_033492 Location (UCSC) Chr 4: 39.5 – 39.53 Mb Chr 5: 65.57 – 65.59 Mb PubMed search [3] [4]
Wikidata
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UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.^[5][6][7]

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.^[7]

This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.

Loss of UGDH has recently been implicated in epileptic encephalopathy in humans^[8]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD⁺ 6-oxidoreductase.

Other names in common use include:

• UDP-glucose dehydrogenase,
• uridine diphosphoglucose dehydrogenase,
• UDPG dehydrogenase,
• UDPG:NAD oxidoreductase,
• UDP-alpha-D-glucose:NAD oxidoreductase,
• UDP-glucose:NAD⁺ oxidoreductase,
• uridine diphosphate glucose dehydrogenase,
• UDP-D-glucose dehydrogenase, and
• uridine diphosphate D-glucose dehydrogenase.

In enzymology, a UDP-glucose 6-dehydrogenase (EC 1.1.1.22) is an enzyme that catalyzes the chemical reaction

UDP-glucose + 2 NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ UDP-glucuronate + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are UDP-glucose, NAD⁺, and H₂O, whereas its 3 products are UDP-glucuronate, NADH, and H⁺

References:^{[9][10][11][12]}